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杨静华教授
2014-03-25 10:45   发布范围:公开

杨静华教授,国家杰出青年基金获得者,第四军医大学讲座教授,波士顿大学副教授。从师于著名分子生物学家Tom Maniatis和诺贝尔奖得主Richard Axel,是最早发现双链RNA编辑酶与生物功能的研究者之一,先后在哈佛医学院和哈佛大学做博士后、从事dsRNA编辑理论和生物功能研究。在此期间,以第一作者在《Nature》、《Science》、《PNAS》等杂志上发表过相关论文。1996年暂短回国,任西安第四军医大学教授,荣获96年国家杰出青年,并获得总后科技进步一点奖。1998年成为美国耶鲁大学的助理教授,获得美国国立卫生院的RO1独立研究基金,青年职业发展基金KO2,SusanKomen乳腺癌基金会的研究基金,以及VA蛋白组质谱开发基金,现任波士顿大学副教授,VA医学中心肿瘤外科研究室主任,临床蛋白组研究中心主任,在双链RNA生物功能、广谱抗病毒机制、疾病表观蛋白组学等方面作了大量的开创性工作,研究结果以通讯作者的身份发表在《Mol Cell Biol》、《J Biol Chem》、《J Virol》、《Immunology》、《Circ Res》、《FASEB J》等杂志上。另外,具有很强的组织的领导能力,早在1994年,参与创立了波士顿生物医学协会BBB(Boston Biomedical and Biotech),如今多名成员已经是国内外各知名院校的中坚力量。1998年负责组织了国家自然科学基金“第四届生命科学论坛”。1999年参与创立了中国医学科学院基础研究所蛋白组研究中心。2001年,被选为纽约中美科学技术协会副会长。2006年来到波士顿大学后,积极参加中美科学技术的交流,参与组织了北美中华医学会(ACMA)的组织工作。

代表性论文:

1.Yang J-H, Perreault JP, Labuda D, Usman N, Cedergren R. Mixed DNA/RNA polymers are cleaved by the hammerhead ribozyme. Biochemistry 29(51):11156-60 (1990).

2.Perreault JP, Labuda D, Usman N, Yang J-H, Cedergren R. Relationship between 2'-hydroxyls and magnesium binding in the hammerhead RNA domain: a model for ribozyme catalysis. Biochemistry 30(16): 4020-5 (1991).

3.Yang J-H, Usman N, Chartrand P, Cedergren R. Minimum ribonucleotide requirement for catalysis by the RNA hammerhead domain. Biochemistry 31(21): 5005-9 (1992).

4.Yang J.-H, Cedergren R, Nadal-Ginard B. Catalytic activity of an RNA domain derived from the U6-U4 RNA complex. Science 263(5143): 77-81 (1994).

5.Yang J.-H, Sklar P, Axel R, Maniatis T. Editing of glutamate receptor subunit B pre-mRNA in vitro by site-specific deamination of adenosine. Nature 374(6517): 77-81 (1995).

6.Yang J.-H, Sklar P, Axel R, Maniatis T. Purification and characterization of a human RNA adenosine deaminase for glutamate receptor B pre-mRNA editing. Proc.Natl. Acad. Sci. USA. 94(9): 4354-9 (1997).

7.F. Li, J-H Yang, X Liu, P He, S Ji, J Wang, J Han, N Chen, and L Yao. Human Glioma Cell BT325 Expresses A Proteinase That Converts Human Plasminogen to Kringle 1-5-Containing Fragments.Biochem. Biophy. Res. Comm. 278 (3): 821-825 (2000).

8.F. Li, J-H Yang, N Chen, and L Yao. One-step generation of human angiostatin directly from plasma. Biochem. Biophy. 27(3):325-7 (2000).

9.Rabinovici R, Kabir K, Luo X, Chen M, Su Y, Zhang D, Yang J.-H*, ADAR1 is Involved in the Development of Microvascular Lung Injury. Circ Res 88: 1066 – 1071(2001).

10.K, K., Gelinas, J. P., Chen, M., Chen, D., Zhang, D., Luo, X., Yang J.-H., Carter, D. Rabinovici, R., Characterizing acute pulmonary inflammation in mouse exposed to endotoxin. Shock 17(4):300-303 (2003).

11.Rabinovici R, Zhang D, Su Y, Luo X, Zhao Q, Yang J-.H.: mob-1 and TNF interact to induce microvascular lung injury. Shock 18(3):261-4 (2002).

12.J-H Yang*, Xiaoxing Luo, Yongzhan Nie, Yingjun Su, Qingchuan Zhao, Koroush Kabir, Dexin Zhang, Reuven Rabinovici. Widespread Inosine-containing mRNA in Lymphocytes Regulated by ADAR1 in Response to Inflammation. Immunology 109:15-23 (2003).

13.Y. Nie, K. Wu, J-H. Yang, F. Tian, D. Fan. Induction of T lymphocytes specific to gastric cancer using HLA-A matched allogeneic gastric tumor cells. J. Immunotherapy 26(5) 403-411 (2003).

14.J. Wu, Y. Shi, K. Wu, D. Zhang, J-H Yang, D. Fan, Angiostatin up-regulation in gastric cancer cell SGC7901 inhibits tumorigenesis in nude mice. World J Gastroenterology 9(1): 59-64(2003).

15.Jing-Hua Yang*, Yongzhan Nie, Qingchuan Zhao, Yingjun Su, Marc Pypaert, Haili Su and Reuven Rabinovici. Intracellular Localization of Differentially Regulated ADAR1 Isoforms in Inflammation. J.Biol.Chem. 278(46):45833-42 (2003).

16.Yongzhan Nie, Qingchuan Zhao, Yingjun Su and Jinghua Yang* Subcellular distribution of ADAR1 isoforms is synergistically determined by three nuclear discrimination signals and a regulatory motif. J.Biol.Chem. 279 (13):13249-55 (2004).

17.Shuli Xia, Jing-Hua Yang*, Enbo Ma, Kevin White and Yingyi Xiao and Gabriel Haddad*. Identification of the new targets of Drosophila pre-mRNA deaminase. Physiological Genomics 20;20(2):195-202 (2005).

18.Nie, Y. Ding, L. Kao, P. N. Braun, R. Jinghua, Yang* ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing. Mol Cell Biol 25 (16) 6956-63 (2005).

19.Zhang DX, Wu J, Yang J.-H, Rabinovici R, Fan DM: Large scale production and purification of murine chemokine monokine induced by IFN-gamma (MIG, CXCL9) in insect cells and its angiostatic effects. Prog Biochem Biophysics 32: 975, 2005.

20.ZHANG De-Xin, ZHAO Peng-Tao; ZHAO Qing-Chuan; LUO Xiao-Xing; NIE Yong-Zhan; SU Ying-Jun; YANG Jing-Hua; R.RABINOVICI; FAN Dai-Ming Functional Characterization and Comparison of Four Splicing Alternatives of Mouse Liver A-to-I RNA Editing Enzyme ADAR1 PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS (2006), 7:635-640

21.Yongzhan Nie, Graeme L. Hammond, & Jing-Hua Yang1* Double-stranded RNA editase ADAR1 increases susceptibility to viral infection. J. Virology, 81(2):917-923 (2007).

22.Zhou Fei, Yang Liu, Zhen Yan, Daiming Fan, Alice Alexander, and Jing-Hua Yang*, Targeting viral dsRNA for antiviral prophylaxis, The FASEB Journal fj.09-144915. Published online October 30, 2009.

23.Micah Meltzer, Kimberly Long, Yongzhan Nie, Mayetri Gupta, Jinghua Yang, Monty Montano, “The RNA Editor Gene ADAR1 is Induced in Myoblasts by Inflammatory Ligands and Buffers Stress Response (p 73-80). Clinical and Translational Science, Published Online: Jun 25 2010 10:03AM, DOI: 10.1111/j.1752-8062.2010.00199.x (2010)

24.Zhou Fei, Yang Liu, Zhen Yan, Daiming Fan, Alice Alexander, and Jing-Hua Yang*, Targeting viral dsRNA for antiviral prophylaxis, The FASEB Journal 25:1767-1774 (2011)

25.Tsuruoka N, Arima M, Yoshida N, Okada S, Sakamoto A, Hatano M, Satake H, Arguni E, Wang JY, Yang Jinghua, Nishikura K, Sekiya S, Shozu M, Tokuhisa T.ADAR1 Protein Induces Adenosine-targeted DNA mutations in Senescent Bcl6 Gene-deficient Cells. J. Biological Chem. 288: 826-836 (2013)

26.Judith Olejnik, Jesus Alonso, Kristina M. Schmidt, Zhen Yan, Wei Wang, Andrea Marzi, Hideki Ebihara, Jinghua Yang, Jean L. Patterson, Elena Ryabchikova, and Elke Mühlberger. Ebola virus does not block apoptotic signaling pathways. J. Virol. 87:5384-5396 (2013)

27.Dong Liu, Chaoxu Liu, Junqiang Li, Kazem Azadzoi, Yun Yang, Zhou Fei, Kefeng Dou, Neil W. Kowall, Han-Pil Choi, Fernando Vieira and Jing-Hua Yang, Proteomic Analysis Reveals Differentially Regulated Protein Acetylation in Human Amyotrophic Lateral Sclerosis Spinal Cord. PLOS ONE, 8(12):e80779 (2013)

28.Mingyu Wang, Qiushuang Zhao, Jinghua Yang, Baojie Jiang, Fangzhong Wang, Kuimei Liu, Xu Fang, A Mitogen-Activated Protein Kinase Tmk3 Participates in High Osmolarity Resistance, Cell Wall Integrity Maintenance and Cellulase Production Regulation in Trichoderma reesei. PLOS ONE 8(8):e72189 (2013)

29.Kazem M Azadzoi, Jinghua Yang, Mike B Siroky. Neural regulation of sexual function in men. World Journal of Clinical Urology 2(3): 32-41 (2013)

奖励和荣誉:

1、国家杰出青年基金获得者,1996

2、中国军队科技进步一等奖获得者,第一作者,1997

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